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A blueprint for health technology assessment capacity building: lessons learned from Malta
- Katharina Abraham, Ingelin Kvamme, Sylvana Magrin Sammut, Simone de Vries, Tanya Formosa, Rudy Dupree, Isaac Corro Ramos, Wim Goettsch, Margreet Franken
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- Journal:
- International Journal of Technology Assessment in Health Care / Volume 40 / Issue 1 / 2024
- Published online by Cambridge University Press:
- 29 February 2024, e11
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Objectives
The development and strengthening of health technology assessment (HTA) capacity on the individual and organizational level and the wider environment is relevant for cooperation on HTAs. Based on the Maltese case, we provide a blueprint for building HTA capacity.
MethodsA set of activities were developed based on Pichler et al.’s framework and the starting HTA capacity in Malta. Individual level activities focused on strengthening epidemiological and health economic skills through online and in-person training. On the organizational level, a new HTA framework was developed which was subsequently utilized in a shadow assessment. Awareness campaign activities raised awareness and support in the wider environment where HTAs are conducted and utilized.
ResultsThe time needed to build HTA capacity exceeded the planned two years accommodating the learning progress of the assessors. In addition to the planned trainings, webinars supplemented the online courses, allowing for more knowledge exchange. The advanced online course was extended over time to facilitate learning next to the assessors’ daily tasks. Training sessions were added to implement the new economic evaluation framework, which was utilized in a second shadow assessment. Awareness by decision-makers was achieved with reports, posters, and an article on the current and developing HTA capacity.
ConclusionsIt takes time and much (hands-on) training to build skills for conducting complex assessment such as HTAs. Facilitating exchange with knowledgeable parties is crucial for succeeding as well as the buy-in of local managers motivating staff. Decision-makers need to be on-boarded for the continued success of HTA capacity building.
The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis
- Anne-Sophie D. Enthoven, Shiral S. Gangadin, Lieuwe de Haan, Wim Veling, Erik F. J. de Vries, Janine Doorduin, HAMLETT and OPHELIA Consortium, Marieke J. H. Begemann, Iris E. C. Sommer
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- Journal:
- Psychological Medicine / Volume 53 / Issue 16 / December 2023
- Published online by Cambridge University Press:
- 12 July 2023, pp. 7795-7804
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Background
Childhood trauma may impact the course of schizophrenia spectrum disorders (SSD), specifically in relation to the increased severity of depressive or negative symptoms. The type and impact of trauma may differ between sexes. In a large sample of recent-onset patients, we investigated the associations of depressive and negative symptoms with childhood trauma and whether these are sex-specific.
MethodsA total of 187 first-episode psychosis patients in remission (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment study) and 115 recent-onset SSD patients (Simvastatin study) were included in this cross-sectional study (men: n = 218; women: n = 84). Total trauma score and trauma subtypes were assessed using the Childhood Trauma Questionnaire Short Form; depressive and negative symptoms were rated using the Positive And Negative Symptoms Scale. Sex-specific regression analyses were performed.
ResultsWomen reported higher rates of sexual abuse than men (23.5% v. 7.8%). Depressive symptoms were associated with total trauma scores and emotional abuse ratings in men (β: 0.219–0.295; p ≤ 0.001). In women, depressive symptoms were associated with sexual abuse ratings (β: 0.271; p = 0.011). Negative symptoms were associated with total trauma score and emotional neglect ratings in men (β: 0.166–0.232; p ≤ 0.001). Negative symptoms in women were not linked to childhood trauma, potentially due to lack of statistical power.
ConclusionsDepressive symptom severity was associated with different types of trauma in men and women with recent-onset SSD. Specifically, in women, depressive symptom severity was associated with childhood sexual abuse, which was reported three times as often as in men. Our results emphasize the importance of sex-specific analyses in SSD research.
PP70 Enhancing HTA Processes In The Maltese System For Introducing New Medicines
- Simone de Vries, Katharina Abraham, Sylvana Magrin Sammut, Antonia Formosa, Isaac Corro Ramos, Matthijs Verteegh, Rudy Dupree, Annemieke van der Waal, Margreet Franken, Wim Goettsch
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- Journal:
- International Journal of Technology Assessment in Health Care / Volume 38 / Issue S1 / December 2022
- Published online by Cambridge University Press:
- 23 December 2022, p. S63
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Introduction
Most European countries use Health Technology Assessment (HTA) as input for decisions on reimbursement of (new) medicines. In 2018, following the approval of European Social Funding, the Directorate for Pharmaceutical Affairs (DPA) within the Malta Ministry for Health led a specific Work Package aimed at enhancing knowledge, skills and HTA processes to inform reimbursement decisions.
MethodsSince the start of the project, the Institute for Medical Technology Assessment (iMTA) and the National Health Care Institute of the Netherlands (ZIN) collaborate in providing guidance and training to DPA on relative effectiveness assessments (REAs) and pharmacoeconomic assessments (PEAs) of pharmaceuticals. Several activities were organized: site visits, face-to face interviews with stakeholders, a qualitative assessment of the core process of the Maltese system, health economics training and tutorials, meetings introducing the European Network for Health Technology Assessment (EUnetHTA) and Dutch HTA processes, development of a new framework for assessment, and a shadow assessment.
ResultsOur assessment identified important methodological challenges and crucial processes interdependencies to optimize within the Maltese system. Based on the learnings, DPA created a template based on the EUnetHTA REA assessment format. IMTA created a template to perform PEAs. Currently, a shadow assessment is ongoing in which DPA performs the REA and PEA of a pharmaceutical using the new templates. ZIN and iMTA will provide feedback to DPA on several aspects, including, but not limited to, the PICO, assessment of therapeutic efficacy and safety, identifying uncertainties, input costs and effects, and formulating a clear discussion of the assessment. If necessary, the templates will be adapted during the process. The project will be evaluated and finalized in 2022.
ConclusionsWith the guidance and training provided by iMTA and ZIN, DPA structured and aligned their REA and PEA to enhance their assessment process and to improve the presentation of their HTA report to the two appraisal committees. This project emphasizes the importance of international collaboration to enhance HTA processes within the
PP146 The Use Of Indirect Comparisons For Reimbursement Decision Making In The Netherlands And England
- Rachel Kalf, Dalia Dawoud, Caroline Bregman, Emily Leckenby, Marijke J.S. de Vries, Diana M.J. Delnoij, Marcel L. Bouvy, Wim G. Goettsch
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- Journal:
- International Journal of Technology Assessment in Health Care / Volume 38 / Issue S1 / December 2022
- Published online by Cambridge University Press:
- 23 December 2022, p. S87
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Introduction
Reimbursement decision making is based on a relative effectiveness assessment (REA), which may be combined with a cost-effectiveness assessment, by national Health Technology Assessment (HTA) agencies. These assessments are based on clinical data where new interventions are compared to the current standard of care, which may differ between countries. Since most pivotal trials only include a limited number of interventions, indirect treatment comparisons (ITCs) can be used to compare multiple interventions. The aim of this study was to evaluate the use of ITCs in HTA decision making in the Netherlands and England.
MethodsAll pharmaceutical assessments published between 2015 and 2019 by the National Health Care Institute (ZIN) and the National Institute for Health and Care Excellence (NICE) were reviewed to determine whether an ITC had been used. For detailed analysis we included all assessments of ZIN using an ITC, and a random sample of assessments of NICE using an ITC (10 assessments per publication year).
ResultsBetween 2015 and 2019 a total of 106 and 265 assessments were conducted by ZIN and NICE, respectively. Of these assessments 48 from ZIN and 150 from NICE included an ITC. The detailed analysis showed that pharmaceutical assessments including indirect comparative evidence led to the REA conclusion of similar therapeutic evidence in 57 percent of 48 assessments by ZIN and in 52 percent of 50 assessments by NICE. Reimbursement recommendations including indirect comparative evidence most often resulted in positive recommendations by ZIN (57% assessments), and in restricted recommendations by NICE (50% assessments). Different methods were employed to incorporate indirect comparative evidence, such as naïve ITCs and network meta-analysis.
ConclusionsOur results showed a significant variability in the use of ITCs between NICE and ZIN, which may contribute to differences in their recommendations. Further analysis will provide deeper insight in these differences and may provide suggestions for a clearer international guidance on the use of ITCs for HTA.
Neurobiological correlates of antisociality across adolescence and young adulthood: a multi-sample, multi-method study
- Neeltje E. Blankenstein, Mark de Rooij, Joost van Ginkel, Tom F. Wilderjans, Esther L. de Ruigh, Helena C. Oldenhof, Josjan Zijlmans, Tijs Jambroes, Evelien Platje, Marjan de Vries-Bouw, Susan Branje, Wim H. J. Meeus, Robert R. J. M. Vermeiren, Arne Popma, Lucres M. C. Jansen
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- Journal:
- Psychological Medicine / Volume 53 / Issue 5 / April 2023
- Published online by Cambridge University Press:
- 27 August 2021, pp. 1834-1849
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Background
Antisociality across adolescence and young adulthood puts individuals at high risk of developing a variety of problems. Prior research has linked antisociality to autonomic nervous system and endocrinological functioning. However, there is large heterogeneity in antisocial behaviors, and these neurobiological measures are rarely studied conjointly, limited to small specific studies with narrow age ranges, and yield mixed findings due to the type of behavior examined.
MethodsWe harmonized data from 1489 participants (9–27 years, 67% male), from six heterogeneous samples. In the resulting dataset, we tested relations between distinct dimensions of antisociality and heart rate, pre-ejection period (PEP), respiratory sinus arrhythmia, respiration rate, skin conductance levels, testosterone, basal cortisol, and the cortisol awakening response (CAR), and test the role of age throughout adolescence and young adulthood.
ResultsThree dimensions of antisociality were uncovered: ‘callous-unemotional (CU)/manipulative traits’, ‘intentional aggression/conduct’, and ‘reactivity/impulsivity/irritability’. Shorter PEPs and higher testosterone were related to CU/manipulative traits, and a higher CAR is related to both CU/manipulative traits and intentional aggression/conduct. These effects were stable across age.
ConclusionsAcross a heterogeneous sample and consistent across development, the CAR may be a valuable measure to link to CU/manipulative traits and intentional aggression, while sympathetic arousal and testosterone are additionally valuable to understand CU/manipulative traits. Together, these findings deepen our understanding of the fundamental mechanisms underlying different components of antisociality. Finally, we illustrate the potential of using current statistical techniques for combining multiple datasets to draw robust conclusions about biobehavioral associations.
Properties of Radio Source Host Galaxies
- Wim de Vries
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 20 / Issue 1 / 2003
- Published online by Cambridge University Press:
- 05 March 2013, pp. 6-11
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A brief overview of the current radio source host galaxy state of affairs is given. All the evidence appears to point towards a scenario in which the young radio source expands through the host galaxy on timescales of 105–106 yr, before it ends its life as a large scale FR II radio galaxy. The place and role of the quasars in this evolutionary picture is unclear, however, and remains an issue of debate.
15 - Geographical variation in terrestrial nitrogen budgets across Europe
- from Part III - Nitrogen flows and fate at multiple spatial scales
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- By Wim de Vries, Wageningen University and Research Centre, Adrian Leip, European Commission Joint Research Centre, Gert Jan Reinds, Wageningen University and Research Centre Alterra, Johannes Kros, Alterra, Wageningen University and Research Centre, Jan Peter Lesschen, Wageningen University and Research Centre, Alexander F. Bouwman, Netherlands Environmental Assessment Agency, Bruna Grizzetti, European Commission Joint Research Centre, Fayçal Bouraoui, European Commission Joint Research Centre, Klaus Butterbach-Bahl, Karlsruhe Institute of Technology, Peter Bergamaschi, European Commission Joint Research Centre, Wilfried Winiwarter, International Institute for Applied Systems Analysis
- Edited by Mark A. Sutton, NERC Centre for Ecology and Hydrology, UK, Clare M. Howard, NERC Centre for Ecology and Hydrology, UK, Jan Willem Erisman, Gilles Billen, Albert Bleeker, Peringe Grennfelt, Hans van Grinsven, Bruna Grizzetti
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- The European Nitrogen Assessment
- Published online:
- 16 May 2011
- Print publication:
- 14 April 2011, pp 317-344
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Summary
Executive summary
Nature of the problem
Nitrogen (N) budgets of agricultural systems give important information for assessing the impact of N inputs on the environment, and identify levers for action.
Approaches
N budgets of agro-ecosystems in the 27 EU countries are established for the year 2000, considering N inputs by fertiliser application, manure excretion, atmospheric deposition and crop fixation, and N outputs by plant uptake, gaseous emissions, mineralisation, leaching and runoff.
Country N budgets for agro-ecosystems are based on the models INTEGRATOR, IDEAg, MITERRA and IMAGE. Fine geographic distribution is depicted with the former two models, which have higher spatial resolution. INTEGRATOR is the only available model for calculating non-agricultural terrestrial N budgets systems.
Key findings/state of knowledge
For EU-27, the models estimate a comparable total N input in European agriculture, i.e. 23.3–25.7 Mton N yr−1, but N uptake varies largely from 11.3–15.4 Mton N yr−1, leading to total N surpluses varying from 10.4–13.2 Mton N yr−1. Despite this variation, the overall difference at EU-27 is small for the emissions of NH3 (2.8–3.1 Mton N yr−1) and N2O (0.33–0.43 Mton N yr−1) but estimates vary largely at a regional scale. The estimated sum of N leaching and runoff at EU-27 is roughly equal to the sum of NH3, N2O and NOx emissions to the atmosphere, but estimates vary by a factor two, from 2.7 to 6.3 Mton N yr−1.
[…]
19 - Nitrogen as a threat to the European greenhouse balance
- from Part IV - Managing nitrogen in relation to key societal threats
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- By Klaus Butterbach-Bahl, Karlsruhe Institute of Technology, Eiko Nemitz, Centre for Ecology and Hydrology, Sönke Zaehle, Max Planck Institute for Biogeochemistry, Gilles Billen, University Pierre & Marie Curie, Pascal Boeckx, Ghent University, Jan Willem Erisman, Energy Research Centre of the Netherlands, Josette Garnier, UMR Sisyphe UPMC & CNRS, Rob Upstill-Goddard, UMR Sisyphe UPMC & CNRS, Michael Kreuzer, ETH Zurich Institute of Plant, Animal and Agroecosystem Science, Oene Oenema, Wageningen University and Research Centre, Stefan Reis, Centre for Ecology and Hydrology, Martijn Schaap, TNO Built Environment and Geosciences, David Simpson, Norwegian Meteorological Institute, Wim de Vries, Wageningen University and Research Centre, Wilfried Winiwarter, International Institute for Applied Systems Analysis, Mark A. Sutton, Centre for Ecology and Hydrology
- Edited by Mark A. Sutton, NERC Centre for Ecology and Hydrology, UK, Clare M. Howard, NERC Centre for Ecology and Hydrology, UK, Jan Willem Erisman, Gilles Billen, Albert Bleeker, Peringe Grennfelt, Hans van Grinsven, Bruna Grizzetti
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- The European Nitrogen Assessment
- Published online:
- 16 May 2011
- Print publication:
- 14 April 2011, pp 434-462
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Summary
Executive summary
Nature of the problem
Reactive nitrogen (Nr) is of fundamental importance in biological and chemical processes in the atmosphere–biosphere system, altering the Earth's climate balance in many ways. These include the direct and indirect emissions of nitrous oxide (N2O), atmospheric Nr deposition and tropospheric ozone formation (O3), both of which alter the biospheric CO2 sink, Nr supply effects on CH4 emissions, and the formation of secondary atmospheric aerosols resulting from the emissions of nitrogen oxides (NOx) and ammonia (NH3).
Human production and release of Nr into the environment is thus expected to have been an important driver of European greenhouse balance. Until now, no assessment has been made of how much of an effect European Nr emissions are having on net warming or cooling.
Approaches
This chapter summarizes current knowledge of the role of Nr for global warming. Particular attention is given to the consequences of atmospheric Nr emissions. The chapter draws on inventory data and review of the literature to assess the contribution of anthropogenic atmospheric Nr emissons to the overall change in radiative forcing (between 1750 and 2005) that can be attributed to activities in Europe.
The use of Nr fertilizers has major additional effects on climate balance by allowing increased crop and feed production and larger populations of livestock and humans, but these indirect effects are not assessed here.
11 - Nitrogen flows and fate in rural landscapes
- from Part III - Nitrogen flows and fate at multiple spatial scales
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- By Pierre Cellier, INRA, France, Patrick Durand, INRA, France, Nick Hutchings, University of Aarhus, Ulli Dragosits, Centre for Ecology and Hydrology, Mark Theobald, Technical University of Madrid/Centre for Ecology and Hydrology, Jean-Louis Drouet, INRA, France, Oene Oenema, Wageningen University and Research Centre, Albert Bleeker, Energy Research Centre of the Netherlands, Lutz Breuer, Institute for Landscape Ecology and Resources Management, Tommy Dalgaard, Aarhus University, Sylvia Duretz, INRA, France, Johannes Kros, Alterra, Wageningen University and Research Centre, Benjamin Loubet, UMR Environm & Grandes Cultures, Joergen Eivind Olesen, Aarhus University Department of Agroecology and Environment, Philippe Mérot, INRA, France, Valérie Viaud, INRA, France, Wim de Vries, Wageningen University and Research Centre, Mark A. Sutton, Centre for Ecology and Hydrology
- Edited by Mark A. Sutton, NERC Centre for Ecology and Hydrology, UK, Clare M. Howard, NERC Centre for Ecology and Hydrology, UK, Jan Willem Erisman, Gilles Billen, Albert Bleeker, Peringe Grennfelt, Hans van Grinsven, Bruna Grizzetti
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- The European Nitrogen Assessment
- Published online:
- 16 May 2011
- Print publication:
- 14 April 2011, pp 229-248
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Summary
Executive summary
Nature of the problem
The transfer of nitrogen by either farm management activities or natural processes (through the atmosphere and the hydrological network) can feed into the N cascade and lead to indirect and unexpected reactive nitrogen emissions.
This transfer can lead to large N deposition rates and impacts to sensitive ecosystems. It can also promote further N2O emission in areas where conditions are more favourable for denitrification.
In rural landscapes, the relevant scale is the scale where N is managed by farm activities and where environmental measures are applied.
Approaches
Mitigating nitrogen at landscape scale requires consideration of the interactions between natural and anthropogenic (i.e. farm management) processes.
Owing to the complex nature and spatial extent of rural landscapes, experimental assessments of reactive N flows at this scale are difficult and often incomplete. It should include measurement of N flows in the different compartments of the environment and comprehensive datasets on the environment (soils, hydrology, land use, etc.) and on farm management.
Modelling is the preferred tool to investigate the complex relationships between anthropogenic and natural processes at landscape scale although verification by measurements is required. Up to now, no model includes all the components of landscape scale N flows: farm functioning, short range atmospheric transfer, hydrology and ecosystem modelling.
20 - Nitrogen as a threat to European terrestrial biodiversity
- from Part IV - Managing nitrogen in relation to key societal threats
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- By Nancy B. Dise, Manchester Metropolitan University, Mike Ashmore, University of York, Salim Belyazid, Belyazid Consulting and Communication AB, Albert Bleeker, Energy Research Centre of the Netherlands, Roland Bobbink, Radboud University, Wim de Vries, Wageningen University and Research Centre, Jan Willem Erisman, Energy Research Centre of the Netherlands, Till Spranger, Federal Ministry for the Environment, Nature Conservation and Nuclear Safety, Carly J. Stevens, Open University, Leon van den Berg, Radboud University Nijmegen
- Edited by Mark A. Sutton, NERC Centre for Ecology and Hydrology, UK, Clare M. Howard, NERC Centre for Ecology and Hydrology, UK, Jan Willem Erisman, Gilles Billen, Albert Bleeker, Peringe Grennfelt, Hans van Grinsven, Bruna Grizzetti
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- The European Nitrogen Assessment
- Published online:
- 16 May 2011
- Print publication:
- 14 April 2011, pp 463-494
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Summary
Executive summary
Nature of the problem
Biodiversity is the variability among living organisms, from genes to the biosphere. The value of biodiversity is multifold, from preserving the integrity of the biosphere as a whole, to providing food and medicines, to spiritual and aesthetic well-being.
One of the major drivers of biodiversity loss in Europe is atmospheric deposition of reactive nitrogen (Nr).
Approaches
This chapter focuses on Nr impacts on European plant species diversity; in particular, the number and abundance of different species in a given area, and the presence of characteristic species of sensitive ecosystems.
We summarise both the scientific and the policy aspects of Nr impacts on diversity and identify, using a range of evidence, the most vulnerable ecosystems and regions in Europe.
Key findings/state of knowledge
Reactive nitrogen impacts vegetation diversity through direct foliar damage, eutrophication, acidification, and susceptibility to secondary stress.
Species and communities most sensitive to chronically elevated Nr deposition are those that are adapted to low nutrient levels, or are poorly buffered against acidification. Grassland, heathland, peatland, forest, and arctic/montane ecosystems are recognised as vulnerable habitats in Europe; other habitats may be vulnerable but are still poorly studied.
It is not yet clear if different wet-deposited forms of Nr (e.g. nitrate, NO3− versus ammonium, NH4+) have different effects on biodiversity. However, gaseous ammonia (NH3) can be particularly harmful to vegetation, especially lower plants, through direct foliar damage.
[…]
16 - Integrating nitrogen fluxes at the European scale
- from Part III - Nitrogen flows and fate at multiple spatial scales
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- By Adrian Leip, European Commission Joint Research Centre, Beat Achermann, Federal Office for the Environment Air Pollution Control, Gilles Billen, University Pierre & Marie Curie, Albert Bleeker, Energy Research Centre of the Netherlands, Alexander F. Bouwman, Netherlands Environmental Assessment Agency, Wim de Vries, Wageningen University and Research Centre, Ulli Dragosits, Centre for Ecology and Hydrology, Ulrike Döring, European Commission Joint Research Centre, Dave Fernall, Food and Rural Affairs Kingspool, Markus Geupel, Federal Environment Agency, Germany, Jürg Herolstab, Penny Johnes, University of Reading, Anne Christine Le Gall, INERIS, France, Suvi Monni, European Commission Joint Research Centre, Rostislav Nevečeřal, Czech Hydrometeorological Institute, Lorenzo Orlandini, European Commission – DG AGRI, Michel Prud'homme, International Fertilizer Industry Association, Hannes I. Reuter, Gisxperts gbr, David Simpson, Norwegian Meteorological Institute, Guenther Seufert, European Commission Joint Research Centre, Till Spranger, Federal Ministry for the Environment, Nature Conservation and Nuclear Safety, Mark A. Sutton, Centre for Ecology and Hydrology, John van Aardenne, European Commission Joint Research Center, Maren Voß, Leibniz-Institute of Baltic Sea Research Warnemuende, Wilfried Winiwarter, International Institute for Applied Systems Analysis
- Edited by Mark A. Sutton, NERC Centre for Ecology and Hydrology, UK, Clare M. Howard, NERC Centre for Ecology and Hydrology, UK, Jan Willem Erisman, Gilles Billen, Albert Bleeker, Peringe Grennfelt, Hans van Grinsven, Bruna Grizzetti
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- Book:
- The European Nitrogen Assessment
- Published online:
- 16 May 2011
- Print publication:
- 14 April 2011, pp 345-376
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Summary
Executive summary
Nature of the problem
Environmental problems related to nitrogen concern all economic sectors and impact all media: atmosphere, pedosphere, hydrosphere and anthroposphere.
Therefore, the integration of fluxes allows an overall coverage of problems related to reactive nitrogen (Nr) in the environment, which is not accessible from sectoral approaches or by focusing on specific media.
Approaches
This chapter presents a set of high resolution maps showing key elements of the N flux budget across Europe, including N2 and Nr fluxes.
Comparative nitrogen budgets are also presented for a range of European countries, highlighting the most efficient strategies for mitigating Nr problems at a national scale. A new European Nitrogen Budget (EU-27) is presented on the basis of state-of-the-art Europe-wide models and databases focusing on different segments of Europe's society.
Key findings
From c. 18 Tg Nr yr−1 input to agriculture in the EU-27, only about 7 Tg Nr yr−1 find their way to the consumer or are further processed by industry.
Some 3.7 Tg Nr yr−1 is released by the burning of fossil fuels in the EU-27, whereby the contribution of the industry and energy sectors is equal to that of the transport sector. More than 8 Tg Nr yr−1 are disposed of to the hydrosphere, while the EU-27 is a net exporter of reactive nitrogen through atmospheric transport of c. 2.3 Tg Nr yr−1.
The largest single sink for Nr appears to be denitrification to N2 in European coastal shelf regions (potentially as large as the input of mineral fertilizer, about 11 Tg N yr–1 for the EU-27); however, this sink is also the most uncertain, because of the uncertainty of Nr import from the open ocean.
21 - Nitrogen as a threat to European soil quality
- from Part IV - Managing nitrogen in relation to key societal threats
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- By Gerard Velthof, Wageningen University and Research Centre, Sébastien Barot, IRD-Bioemco, Jaap Bloem, Alterra Wageningen University and Research Centre, Klaus Butterbach-Bahl, Karlsruhe Institute of Technology, Wim de Vries, Wageningen University and Research Centre, Johannes Kros, Alterra, Wageningen University and Research Centre, Patrick Lavelle, INRA, Colombia, Jørgen Eivind Olesen, Aarhus University Department of Agroecology and Environment, Oene Oenema, Wageningen University and Research Centre
- Edited by Mark A. Sutton, NERC Centre for Ecology and Hydrology, UK, Clare M. Howard, NERC Centre for Ecology and Hydrology, UK, Jan Willem Erisman, Gilles Billen, Albert Bleeker, Peringe Grennfelt, Hans van Grinsven, Bruna Grizzetti
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- Book:
- The European Nitrogen Assessment
- Published online:
- 16 May 2011
- Print publication:
- 14 April 2011, pp 495-510
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Summary
Executive summary
Nature of the problem
A large part of agricultural soils in Europe are exposed to high N inputs because of animal manure and chemical fertiliser use. Large parts of the European natural soils are exposed to high atmospheric N deposition.
High N inputs threaten soil quality, which may negatively affect food and biomass production and biodiversity and enhance emissions of harmful N compounds from soils to water and the atmosphere.
Approaches
An overview of the major soil functions and soil threats are presented, including a description of the objectives of the European Soil Strategy.
The major N threats on soil quality for both agricultural and natural soils are related to changes in soil organic content and quality, soil acidification, and loss of soil diversity. These threats are described using literature.
Key findings/state of knowledge
Generally, N has a positive effect on soil quality of agricultural soils, because it enhances soil fertility and conditions for crop growth. However, it generally has a negative effect on soil quality of natural soils, because it results in changes in plant diversity.
Soil acts as a filter and buffer for N, and protects water and atmosphere against N pollution. However, the filter and buffer capacity of soils is frequently exceeded by excess of N in both agricultural and natural soils, which results in emission of N to the environment.
[…]
24 - Future scenarios of nitrogen in Europe
- from Part V - European nitrogen policies and future challenges
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- By Wilfried Winiwarter, International Institute for Applied Systems Analysis, Jean-Paul Hettelingh, National Institute for Public Health and the Environment, Alex F. Bouwman, Netherlands Environmental Assessment Agency, Wim de Vries, Wageningen University and Research Centre, Jan Willem Erisman, Energy Research Centre of the Netherlands, James Galloway, University of Virginia, Zbigniew Klimont, International Institute for Applied Systems Analysis, Allison Leach, University of Virginia, Adrian Leip, European Commission Joint Research Centre, Christian Pallière, Fertilizers Europe, Uwe A. Schneider, KlimaCampus, Hamburg University, Till Spranger, Federal Ministry for the Environment, Nature Conservation and Nuclear Safety, Mark A. Sutton, Centre for Ecology and Hydrology, Anastasia Svirejeva-Hopkins, Potsdam Institute for Climate Impact Research, Klaas W. van der Hoek, National Institute for Public Health and the Environment, Peter Witzke, EuroCARE GmbH
- Edited by Mark A. Sutton, NERC Centre for Ecology and Hydrology, UK, Clare M. Howard, NERC Centre for Ecology and Hydrology, UK, Jan Willem Erisman, Gilles Billen, Albert Bleeker, Peringe Grennfelt, Hans van Grinsven, Bruna Grizzetti
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- Book:
- The European Nitrogen Assessment
- Published online:
- 16 May 2011
- Print publication:
- 14 April 2011, pp 551-569
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Summary
Executive summary
Nature of the problem
The future effects of nitrogen in the environment will depend on the extent of nitrogen use and the practical application techniques of nitrogen in a similar way as in the past. Projections and scenarios are appropriate tools for extrapolating current knowledge into the future. However, these tools will not allow future system turnovers to be predicted.
Approaches
In principle, scenarios of nitrogen use follow the approaches currently used for air pollution, climate, or ecosystem projections. Short-term projections (to 2030) are developed using a ‘baseline’ path of development, which considers abatement options that are consistent with European policy. For medium-term projections (to 2050) and long-term projections, the European Nitrogen Assessment (ENA) applies a ‘storyline’ approach similar to that used in the IPCC SRES scenarios. Beyond 2050 in particular, such storylines also take into account technological and behavioral shifts.
Key findings/state of knowledge
The ENA distinguishes between driver-oriented and effect-oriented factors determining nitrogen use. Parameters that cause changes in nitrogen fixation or application are called drivers. In a driver-based approach, it is assumed that any variation of these parameters will also trigger a change in nitrogen pollution. In an effect-based approach, as the adverse effects of nitrogen become evident in the environment, introduction of nitrogen abatement legislation requiring the application of more efficient abatement measures is expected. This approach needs to rely on a target that is likely to be maintained in the future (e.g. human health). Nitrogen abatement legislation based on such targets will aim to counter any growth in adverse environmental effects that occur as a result of increased nitrogen application.
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CHAPTER 6 - ENVIRONMENTAL AND HEALTH IMPACTS OF AIR POLLUTION
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- By Mike Ashmore, University of York, Wim de Vries, Alterra Green World Research, Jean-Paul Hettelingh, Netherlands Environmental Assessment Agency (MNP), Kevin Hicks, University of York, Maximilian Posch, Netherlands Environmental Assessment Agency (MNP), Gert Jan Reinds, Alterra Green World Research, Fred Tonneijck, Wageningen University and Research Centre, Leendert van Bree, Netherlands Environmental Assessment Agency (MNP), Han van Dobben, Alterra Green World Research
- Edited by Ranjeet Sokhi
- Foreword by Mario Molina
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- Book:
- World Atlas of Atmospheric Pollution
- Published by:
- Anthem Press
- Published online:
- 05 March 2012
- Print publication:
- 03 May 2008, pp 77-94
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Summary
Air pollution is known to have a range of effects, including those on human health, crop production, soil acidification, visibility and corrosion of materials. This Chapter focuses on the two major impacts of air pollution that have most strongly influenced the development of policies to reduce emissions: those on the natural environment and on human health.
In broad terms, the major impacts of air pollution on the natural environment can be placed into three categories, representing different spatial scales:
Local impacts of major industrial or urban sources, for example, instances of damage to ecosystems and crop production close to emission sources. Historically, the biggest impacts have been through the direct effects of sulphur dioxide and particles – either around large point sources such as power stations and smelters, or in urban areas with domestic coal burning – and the accumulation of toxic metals in soils around smelters. However, a range of other pollutants from specific local sources can have direct impacts on vegetation.
Regional impacts of ozone, which is a significant global air pollutant in terms of impacts on vegetation, since high concentrations are found in rural areas.
Regional impacts of long-Range Transport and deposition of sulphur and nitrogen, which have effects on soil acidity, nutrient availability and water chemistry, and hence on ecosystem composition and function.
The Chapter first considers direct effects of air pollution on vegetation and the visible symptoms of damage that can result, illustrating the spatial variation in damage by reference to national and local studies in the Netherlands.
Jet-induced star formation: Good news from big, bad black holes
- Wil van Breugel, Chris Fragile, Stephen Croft, Wim de Vries, Peter Anninos, Stephen Murray
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- Journal:
- Proceedings of the International Astronomical Union / Volume 2004 / Issue IAUS222 / March 2004
- Published online by Cambridge University Press:
- 01 December 2004, pp. 485-488
- Print publication:
- March 2004
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- Article
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- You have access Access
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We discuss obbservations and numerical simulations which show that radiative shocks in jet-cloud collisions can trigger the collapse of intergalactic clouds and subsequent star formation in low luminosity, ‘FR-I’ type, radio galaxies.
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